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KMID : 0379519980140040501
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한국독성학회지
1998 Volume.14 No. 4 p.501 ~ p.505
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Acute Oral Toxicity of A Novel Combined Antibiotic(Cefatrizine / Clavulanic Acid) in Rats
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Kwon Jong-Won
Kang Kyung-Koo
Hyun Cho
Baik Nam-Gi
Ahn Byoung-Ok
Kim Gye-Won
Kim Won-Bae
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Abstract
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The acute toxicity study of combined antibiotic (Cefatrizine / Clavulanic Acid), a formulation consisting of cafatrizine and clavulanic acid in a ratio of 2 : 1, was evaluated in rats. The antibiotic was orally administered with single dose in dose levels up to 5 g/kg (0, 1.25, 2.5, 5 g/kg). Treatment-related effects were limited to soft stool excretion and caecal dilatation, but histologically no morphological changes could be detected in caecum. In hematology, serum-chemistry parameters and histopathology, no drug-related changes were found. The results of the present study indicate that cefatrizine / clavulanic acid has a low toxic potential and the oral LD_{50}values exceed 5 g / kg in rats
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KEYWORD
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Combined antibiotic (Ciifatrizine/Clavulanic acid), Toxicity, Rat
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